Description
| VIP 10 mg | |
|---|---|
| SKU | CP_VIP_10MG_3ML_VIAL |
| CATEGORY | Lyophilized Peptide |
| CAS | 37221-79-7 |
| VIAL SIZE | 3 mL |
| FORM | LYOPHILIZED POWDER (Acetate salt) |
| MOLECULAR WEIGHT | 3326.8 g/mol |
| SEQUENCE | His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn |
| MOLECULAR FORMULA | C147H237N43O43S |
| ITEM ID | 28505 |
VIP-expressing interneurons (VIP-INs) are a focus of active neuroscience research. In a study using pathway-specific electrophysiology with optogenetic and chemogenetic manipulations in mouse hippocampal CA1, Iloun et al. (2026) reported that VIP-INs provide direct inhibitory synaptic input to pyramidal neurons in both superficial and deep sublayers. Chemogenetic silencing of VIP-INs uncovered sublayer- and pathway-specific disinhibitory motifs: during Schaffer collateral activation, VIP-IN silencing preferentially reduced inhibition onto deep pyramidal cells, while during temporoammonic input processing, distinct sublayer-specific effects on excitatory and inhibitory drive were observed. These findings characterize VIP-INs as pathway- and sublayer-specific modulators of excitation-inhibition balance in the mouse hippocampus [1].
